Human and Macaque Monkey Cerebellum Unfolding Movies


From:

Sereno, M.I., J. Diedrichsen, M. Tachrount, G. Testa-Silva, H. d'Arceuil, and C. De Zeeuw (2020)
The human cerebellum has almost 80% of the surface area of the neocortex.
Proceedings of the National Academy of Sciences USA 117:19538-19543.
(doi: 10.1073/pnas.2002896117)

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Movie S1 (loop)

Unfolding and refolding the reconstructed surface of the middle layers of human cerebellar cortex (movie loop). The initially folded reconstruction rotates, unfolds, and then refolds, first in posterior, then in anterior view. The deep fissures between the lobules are revealed as the surface unfolds. The near-midline cerebellar tonsils are visible in the anterior view (at 00:25 to 00:30). Because of the substantial intrinsic curvature of the cerebellar surface, the unfolded 'bubbles' formed by each lobule cannot be further unfolded/inflated without severe distortion.

https://pages.ucsd.edu/~msereno/cereb/movies/sereno-human-cereb-unfold.mov


Movie S2 (loop)

Unfolding and refolding the reconstructed surface of the middle layers of macaque monkey cerebellar cortex (movie loop). The initially folded reconstruction rotates, unfolds, and refolds in parallel with the first movie (SI Appendix, Movie S1). By comparing the two movies, the huge expansion of the hemispheres relative to the vermis in humans, especially posteriorly, is quite apparent. Note that the much smaller monkey surface is not to same scale as the human surface (see Fig. 2 for true relative sizes of the surfaces).

https://pages.ucsd.edu/~msereno/cereb/movies/sereno-monk-cereb-unfold.mov


Cut lateral hemisphere rotates (loop)

The lateral half of the right hemisphere has been cut off and then rotated to allow viewing the complexly folded surface from the inside (white).

https://pages.ucsd.edu/~msereno/cereb/movies/sereno-human-cereb-cut.mp4


Spherical morph rotates (loop)

A spherical morph of the entire cerebellar surface rotates, starting from an anterior (ventral) view, with the cut peduncles, the flocculi, the tonsils, and the vermis visible. Note that the representation here of the original local surface area is extremely distorted because of the large and locally variable amount of intrinsic (Gaussian) curvature.

https://pages.ucsd.edu/~msereno/cereb/movies/sereno-human-cereb-sphererot.mp4



(N.B.: the S1/S2 movies are L/R mirror images of sample cerebellum)
(N.B.: QuickTime Player can L/R flip)